Cats once best friends are now enemies.?

  I have two cats, one male and one female. The male cat, Shadow, is neutered. The female cat, Kiki, is not (I know this is irresponsible but I am a vet tech student right now and can get it done for much cheaper at school in the spring ... so I'm waiting.) They used to be BEST FRIENDS. I mean the works, cuddling, grooming eachother, always together ..



Then, yesterday, Shadow got outside for like an hour tops. When I brought him back inside, Kiki FLIPPED. She wanted to kill him. There was a huge scuffle inside my house it sounded like the house was going to fall apart. The weirdest thing about it all was the fact that once I separated kiki from Shadow by putting her in my bedroom, she sniffed around aimlessly as if she did not recognize where she was. She seems to not recognize any of the old familiar scents.



I am so distraught over this. My cats used to love eachother and every time I have to break up a fight, I get more "battle scars". My teachers at school gave me feliway (bottled cat pheromones in a glade plug in type of stimulator) and said to give it a week or two to see what happens, but to me this seems like a patch and not an answer as to why this happened in the beginning. pets question and answers,www.5d2d.com



How can she just flip like that. She seems completely healthy. Rabies is not it either because she had a 3 year vaccine just a year ago. She seems like a different cat. Even her meow is different.



Please if you have had any similar experiences let me know. I'm very upset and worried that there may be something physiologically wrong with my cat, but I sure don't want to pay a vet bill if this is just something as simple as she's having a hormone influx and Shadow smells like another male cat.
I would separate them and reintroduce them to each other as if one of them were new. Put one of them at a time in a dog crate until they stop behaving badly to one another. Patch or not, the Feliway is a good idea. It can help you get through the crisis.



It's not unusual for a cat to attack a cat that comes home smelling funny, but I've never heard of it lasting for very long. If this was just yesterday, I wouldn't worry too much.